BDBM50095507 4-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-butyric acid::CHEMBL342295::CHEMBL371867

SMILES OC(=O)C(=O)CC(=O)c1cccn1Cc1ccccc1

InChI Key InChIKey=MPDGLRXQNTUOLY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50095507   

TargetIntegrase(Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095507(CHEMBL371867 | CHEMBL342295 | 4-(1-Benzyl-1H-pyrro...)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50095507(CHEMBL371867 | CHEMBL342295 | 4-(1-Benzyl-1H-pyrro...)
Affinity DataIC50: 2.90E+4nMpH: 7.5Assay Description:Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095507(CHEMBL371867 | CHEMBL342295 | 4-(1-Benzyl-1H-pyrro...)
Affinity DataIC50: 220nMAssay Description:Strand transfer inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed