BDBM50095502 4-(5-Benzyl-thiophen-2-yl)-2,4-dioxo-butyric acid::CHEMBL196421::CHEMBL358506

SMILES OC(=O)C(=O)CC(=O)c1ccc(Cc2ccccc2)s1

InChI Key InChIKey=PHCFKAVFHIELCJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50095502   

TargetIntegrase(Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095502(CHEMBL196421 | CHEMBL358506 | 4-(5-Benzyl-thiophen...)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant HIV-1 Integrase in strand transfer enzyme assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50095502(CHEMBL196421 | CHEMBL358506 | 4-(5-Benzyl-thiophen...)
Affinity DataIC50: 6.80E+4nMpH: 7.5Assay Description:Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095502(CHEMBL196421 | CHEMBL358506 | 4-(5-Benzyl-thiophen...)
Affinity DataIC50: 500nMAssay Description:Strand transfer inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed