BDBM50095489 CHEMBL275080::N-(1-Cyano-pyrrolidin-3-yl)-benzenesulfonamide::N-(1-cyanopyrrolidin-3-yl)benzenesulfonamide::US11414402, Example 5

SMILES O=S(=O)(NC1CCN(C1)C#N)c1ccccc1

InChI Key InChIKey=FXILBKWGQQHVJE-UHFFFAOYSA-N

Data  1 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50095489   

TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095489(N-(1-Cyano-pyrrolidin-3-yl)-benzenesulfonamide | N...)
Affinity DataIC50: 750nMAssay Description:Inhibitory activity tested against Human Cathepsin K receptor using bone resorption assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095489(N-(1-Cyano-pyrrolidin-3-yl)-benzenesulfonamide | N...)
Affinity DataIC50: 18nMAssay Description:Inhibitory activity tested against Human Cathepsin K receptor using gelatinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095489(N-(1-Cyano-pyrrolidin-3-yl)-benzenesulfonamide | N...)
Affinity DataIC50: 81nMAssay Description:Inhibitory constant against human cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095489(N-(1-Cyano-pyrrolidin-3-yl)-benzenesulfonamide | N...)
Affinity DataIC50: 80nMAssay Description:Inhibitory activity tested against Human Cathepsin L using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095489(N-(1-Cyano-pyrrolidin-3-yl)-benzenesulfonamide | N...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity tested against Human Cathepsin B using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095489(N-(1-Cyano-pyrrolidin-3-yl)-benzenesulfonamide | N...)
Affinity DataIC50: 50nMAssay Description:Inhibitory activity tested against Human Cathepsin K using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPapain(Papaya)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095489(N-(1-Cyano-pyrrolidin-3-yl)-benzenesulfonamide | N...)
Affinity DataIC50: 230nMpH: 5.5Assay Description:Inhibitory activity tested against papain at a pH 5.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM50095489(N-(1-Cyano-pyrrolidin-3-yl)-benzenesulfonamide | N...)
Affinity DataIC50: 5.50E+4nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent

TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095489(N-(1-Cyano-pyrrolidin-3-yl)-benzenesulfonamide | N...)
Affinity DataKi:  90nMAssay Description:Inhibitory constant against human cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed