BDBM50095261 (3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine::4-(3'-chloroanilino)-6,7-diethoxyquinazoline hydrochloride::CHEMBL64950

SMILES CCOc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OCC

InChI Key InChIKey=VXCUTOVXETTYDM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50095261   

TargetFructose-1,6-bisphosphatase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095261(4-(3'-chloroanilino)-6,7-diethoxyquinazoline hydro...)
Affinity DataIC50: 1.60E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Pig)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095261(4-(3'-chloroanilino)-6,7-diethoxyquinazoline hydro...)
Affinity DataIC50: 3.90E+3nMAssay Description:Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095261(4-(3'-chloroanilino)-6,7-diethoxyquinazoline hydro...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was evaluated for its concentration required to inhibit the rat liver F16BPaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Lawrence Berkeley National Laboratory

Curated by ChEMBL
LigandPNGBDBM50095261(4-(3'-chloroanilino)-6,7-diethoxyquinazoline hydro...)
Affinity DataIC50: 0.380nMAssay Description:Displacement of [125I]4-(3-iodoanilino)-6,7-dimethoxyquinazoline from EGFR tyrosine kinase in human A431 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Lawrence Berkeley National Laboratory

Curated by ChEMBL
LigandPNGBDBM50095261(4-(3'-chloroanilino)-6,7-diethoxyquinazoline hydro...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human EGFR tyrosine kinase phosphorylation expressed in mouse BaF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095261(4-(3'-chloroanilino)-6,7-diethoxyquinazoline hydro...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human liver FBPaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed