BDBM50094841 (+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid::(-)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid::(1S,2S,3S,5R,6S)-2-amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid::2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid::CHEMBL334014

SMILES N[C@@]1([C@H]2[C@@H](C[C@@H]1F)[C@@H]2C(O)=O)C(O)=O

InChI Key InChIKey=DIWVNJFXRKZAGI-UHFFFAOYSA-N

Data  2 KI  6 IC50  14 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50094841   

TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50:  97nMAssay Description:Agonist activity at rat mGlu3 receptor expressed in CHO cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human mGlu8 receptor expressed in CHO cell membranes in presence of glutamate by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human mGlu6 receptor expressed in HEK293T cell membranes in presence of glutamate by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human mGlu4 receptor expressed in CHO cell membranes in presence of glutamate by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human mGlu1 receptor expressed in CHO cell membranes in presence of glutamate by intracellular Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in CHO cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human mGlu6 receptor expressed in HEK293T cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human mGlu1 receptor expressed in CHO cell membranes by intracellular Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human mGlu4 receptor expressed in CHO cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human mGlu3 receptor expressed in CHO cell membranes in presence of glutamate by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human mGlu2 receptor expressed in CHO cell membranes in presence of glutamate by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50:  29.4nMAssay Description:Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50:  154nMAssay Description:Agonist activity at rat mGlu2 receptor expressed in CHO cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50:  76nMAssay Description:Agonist activity at human mGlu3 receptor expressed in CHO cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50:  153nMAssay Description:Agonist activity at human mGlu2 receptor expressed in CHO cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50:  2.64E+3nMAssay Description:Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated in presence of 30 uM glutamic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50:  29.4nMAssay Description:Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50:  45.4nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity against Metabotropic glutamate receptor 3 expressed in CHO cells was evaluated in presence of 30 uM glutamic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataKi:  47.7nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 2 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataKi:  65.9nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 3 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed