BDBM50094634 CHEMBL140979::N-(4-Amino-2-methyl-quinolin-6-yl)-2-(4-ethyl-phenoxymethyl)-benzamide::N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylphenoxy)methyl)benzamide::US20240246941, Compound SJ000855285

SMILES CCc1ccc(OCc2ccccc2C(=O)Nc2ccc3nc(C)cc(N)c3c2)cc1

InChI Key InChIKey=VTGBZWHPJFMTKS-UHFFFAOYSA-N

Data  8 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50094634   

TargetNociceptin receptor(Human)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50094634(N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylpheno...)
Affinity DataIC50: 30nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human NOP receptor expressed in human HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50094634(N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylpheno...)
Affinity DataIC50: 7.51E+3nMAssay Description:Displacement of [3H]-naltrindole from human kappa opioid receptor expressed in human HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50094634(N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylpheno...)
Affinity DataIC50: 1.51E+3nMAssay Description:Displacement of [3H]-naltrindole from human mu opioid receptor expressed in CHO cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetMelanoma-associated antigen E1(Human)
ST. JUDE CHILDREN''S RESEARCH HOSPITAL, INC.

US Patent
LigandPNGBDBM50094634(N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylpheno...)
Affinity DataIC50: 9.29E+3nMAssay Description:The TR-FRET assay buffer with a formula of 50 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml BSA and 1 mM DTT was freshly prepared before each experiment. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
Go to US Patent

TargetNociceptin receptor(Human)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50094634(N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylpheno...)
Affinity DataKi:  8.20nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50094634(N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylpheno...)
Affinity DataKi:  8.20nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding against human Opioid receptor like 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50094634(N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylpheno...)
Affinity DataKi:  102nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding using COS-human Opioid receptor mu 1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50094634(N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylpheno...)
Affinity DataKi:  103nMAssay Description:Inhibition of [3H]diprenorphine (0.33 nM) binding from human Opioid receptor mu 1 expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50094634(N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylpheno...)
Affinity DataKi:  1.06E+3nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding using COS-human Opioid receptor kappa 1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50094634(N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylpheno...)
Affinity DataKi:  1.06E+3nMAssay Description:Inhibition of [3H]naltrindole (0.55 nM) binding from human Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094634(N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylpheno...)
Affinity DataKi:  8.65E+3nMAssay Description:Inhibition of [3H]naltrindole (0.55 nM) binding from human Opioid receptor delta 1 expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094634(N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylpheno...)
Affinity DataKi:  8.65E+3nMAssay Description:Binding affinity for opioid receptor type, human Opioid receptor delta 1 expressed in membrane homogenates of COS-1 or CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed