BDBM50094606 CHEMBL3589009::US9284299, iCRT3::US9738628, Compound iCRT3

SMILES CCc1ccc(cc1)-c1nc(CSCC(=O)NCCc2ccccc2)c(C)o1

InChI Key InChIKey=QTDYVSIBWGVBKU-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50094606   

TargetCatenin beta-1 [138-686](Human)
University of Utah Research Foundation

US Patent
LigandPNGBDBM50094606(CHEMBL3589009 | US9284299, iCRT3 | US9738628, Comp...)
Affinity DataKi:  3.65E+5nM ΔG°:  -4.69kcal/moleT: 2°CAssay Description:Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details
Go to US Patent

TargetCatenin beta-1 [138-686](Human)
University of Utah Research Foundation

US Patent
LigandPNGBDBM50094606(CHEMBL3589009 | US9284299, iCRT3 | US9738628, Comp...)
Affinity DataKi:  1.95E+5nM ΔG°:  -5.06kcal/molepH: 7.4 T: 2°CAssay Description:Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details
Go to US Patent

TargetCatenin beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50094606(CHEMBL3589009 | US9284299, iCRT3 | US9738628, Comp...)
Affinity DataKi:  3.70E+5nMAssay Description:Inhibition of human wild-type beta-catenin (residues 138-686)/C-terminally fluorescein labeled human wild-type Tcf4 (residues 7-51) interaction after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetCatenin beta-1 [138-686](Human)
University of Utah Research Foundation

US Patent
LigandPNGBDBM50094606(CHEMBL3589009 | US9284299, iCRT3 | US9738628, Comp...)
Affinity DataKi:  1.95E+5nMAssay Description:Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent

TargetCatenin beta-1 [138-686](Human)
University of Utah Research Foundation

US Patent
LigandPNGBDBM50094606(CHEMBL3589009 | US9284299, iCRT3 | US9738628, Comp...)
Affinity DataKi:  3.65E+5nMAssay Description:Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent

TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50094606(CHEMBL3589009 | US9284299, iCRT3 | US9738628, Comp...)
Affinity DataKi:  3.65E+5nMAssay Description:Inhibition of beta-Catenin/TCF4 (unknown origin) protein-protein interaction assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed