BDBM50094513 1,1,1-Trifluoro-3-{(3-phenoxy-phenyl)-[3-(1,1,2,2-tetrafluoro-ethoxy)-benzyl]-amino}-propan-2-ol::1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(1,1,2,2-tetrafluoroethoxy)benzyl)amino)propan-2-ol::3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-phenoxyphenyl)amino)-1,1,1-trifluoropropan-2-ol::CHEMBL297971

SMILES OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F

InChI Key InChIKey=XNYMOOHZPFZFJE-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50094513   

TargetCholesteryl ester transfer protein(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50094513(1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(1,1,2,2-te...)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human CETP-mediated transfer of [3H]CE from HDL to LDLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholesteryl ester transfer protein(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50094513(1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(1,1,2,2-te...)
Affinity DataIC50: 6.00E+3nMAssay Description:Tested for inhibiting CETP-mediated transfer of [3H]-CE from HDL to LDL in vitro under buffered assay conditions in human serum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholesteryl ester transfer protein(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50094513(1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(1,1,2,2-te...)
Affinity DataIC50: 200nMAssay Description:In vitro human CETP inhibitory activity was assessed by measuring the rate of [3H]cholesteryl ester ([3H]CE) from HDL donor particles to LDL acceptor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholesteryl ester transfer protein(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50094513(1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(1,1,2,2-te...)
Affinity DataIC50: 140nMAssay Description:Concentration required for 50% inhibition of cholesteryl ester transfer protein in presence of buffer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholesteryl ester transfer protein(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50094513(1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(1,1,2,2-te...)
Affinity DataIC50: 1.20E+4nMAssay Description:Concentration required for 50% Inhibition against Cholesteryl ester transfer protein (CETP) mediated transfer in cholesterol fed hamster serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholesteryl ester transfer protein(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50094513(1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(1,1,2,2-te...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of cholesteryl ester transfer protein in presence of human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholesteryl ester transfer protein(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50094513(1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(1,1,2,2-te...)
Affinity DataIC50: 6.00E+3nMAssay Description:Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholesteryl ester transfer protein(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50094513(1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(1,1,2,2-te...)
Affinity DataIC50: 140nMAssay Description:Compound was tested in vitro for inhibitory activity against recombinant human cholesteryl ester transfer protein in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholesteryl ester transfer protein(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50094513(1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(1,1,2,2-te...)
Affinity DataIC50: 140nMAssay Description:Inhibition of CETPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholesteryl ester transfer protein(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50094513(1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(1,1,2,2-te...)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human CETP in buffer assessed as transfer of [3H]-cholesteryl ester from HDL donor particles to LDL acceptor particlesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetCholesteryl ester transfer protein(Rabbit)
Al-Zaytoonah Private University of Jordan

Curated by ChEMBL
LigandPNGBDBM50094513(1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(1,1,2,2-te...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CETP in rabbit serum after 1 hr by fluorescent cholesteryl esters transfer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed