BDBM50094503 2-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-1H-indole-5-carbonitrile::2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-indole-5-carbonitrile::CHEMBL143761

SMILES Fc1ccc(cc1)N1CCN(Cc2cc3cc(ccc3[nH]2)C#N)CC1

InChI Key InChIKey=VEYSGMPQWOSGTB-UHFFFAOYSA-N

Data  13 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50094503   

TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50094503(2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-in...)
Affinity DataEC50:  9.40nMAssay Description:Effective dose was measured by the stimulation of mitogenesis at dopamine D4.2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50094503(2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-in...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]spiperone from human Dopamine receptor D4.4 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50094503(2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-in...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50094503(2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-in...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-spiperone from human D4 receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetD(1A) dopamine receptor(Bovine)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50094503(2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-in...)
Affinity DataKi:  8.60E+3nMAssay Description:Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Pig)
University of Tours

Curated by ChEMBL
LigandPNGBDBM50094503(2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-in...)
Affinity DataKi:  8.60E+3nMAssay Description:Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50094503(2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-in...)
Affinity DataKi:  1.50E+4nMAssay Description:Displacement of [3H]spiperone from human Dopamine receptor D3 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50094503(2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-in...)
Affinity DataKi:  1.50E+4nMAssay Description:Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50094503(2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-in...)
Affinity DataKi:  1.50E+4nMAssay Description:Binding affinity to human D3R assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50094503(2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-in...)
Affinity DataKi:  1.90E+4nMAssay Description:Displacement of [3H]spiperone from human Dopamine receptor D2S expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50094503(2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-in...)
Affinity DataKi:  1.90E+4nMAssay Description:Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50094503(2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-in...)
Affinity DataKi:  2.80E+4nMAssay Description:Displacement of [3H]spiperone from human Dopamine receptor D2L expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50094503(2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-in...)
Affinity DataKi:  2.80E+4nMAssay Description:Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50094503(2-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-in...)
Affinity DataKi:  2.80E+4nMAssay Description:Binding affinity to human D2R assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed