BDBM50094298 CHEMBL16117::N-[(S)-1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-butyramide::N-[1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-butyramide::Philanthotoxin-343

SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCNCCCCNCCCN

InChI Key InChIKey=DTWANULJDRVTFI-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50094298   

TargetMetabotropic glutamate receptor 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50094298(N-[1-{3-[4-(3-Amino-propylamino)-butylamino]-propy...)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at GluR1 expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced current at -60mV holding potential by tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50094298(N-[1-{3-[4-(3-Amino-propylamino)-butylamino]-propy...)
Affinity DataIC50: 2.74E+3nMAssay Description:Antagonist activity at NR1-1a/NR2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at -60mV ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit delta(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50094298(N-[1-{3-[4-(3-Amino-propylamino)-butylamino]-propy...)
Affinity DataIC50: 7.50E+4nMAssay Description:Compound was evaluated for inhibitory activity against human embryonic muscle type Nicotinic acetylcholine receptor specifically delta-subunit expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
University of California

Curated by ChEMBL
LigandPNGBDBM50094298(N-[1-{3-[4-(3-Amino-propylamino)-butylamino]-propy...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50094298(N-[1-{3-[4-(3-Amino-propylamino)-butylamino]-propy...)
Affinity DataIC50: 1.18E+4nMAssay Description:Antagonist activity at human muscle-type nAChR (embryonic muscle) expressed in TE671 cells; (end value).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50094298(N-[1-{3-[4-(3-Amino-propylamino)-butylamino]-propy...)
Affinity DataIC50: 5.67E+4nMAssay Description:Antagonist activity at human muscle-type nAChR (embryonic muscle) expressed in TE671 cells; (peak value).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50094298(N-[1-{3-[4-(3-Amino-propylamino)-butylamino]-propy...)
Affinity DataIC50: 7.70nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50094298(N-[1-{3-[4-(3-Amino-propylamino)-butylamino]-propy...)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at alpha4beta2 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed