BDBM50093600 17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15-dodecahydro-cyclopenta[a]phenanthren-3-one::CHEMBL135351

SMILES CC(N=O)C1=CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C

InChI Key InChIKey=PFTADDLKLSJPSP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50093600   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093600(17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8...)
Affinity DataIC50: 100nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
University of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093600(17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8...)
Affinity DataIC50: 1.00E+4nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type 2 from human BPH tissue at 210 nM of testosteroneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
University of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093600(17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8...)
Affinity DataIC50: 1.00E+4nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type I in human DU-145 cell assay at 5 nM of androstenedioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rat)
University of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093600(17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8...)
Affinity DataIC50: 1.25E+5nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 rat enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed