BDBM50093592 17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one::CHEMBL137040

SMILES CC(CC1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C)N=O

InChI Key InChIKey=KNTLRRMPVIPDDX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50093592   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rat)
University of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093592(17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,2,6,7,...)
Affinity DataIC50: 3.60E+3nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 rat enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
University of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093592(17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,2,6,7,...)
Affinity DataIC50: 900nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type I in human DU-145 cell assay at 5 nM of androstenedioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093592(17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,2,6,7,...)
Affinity DataIC50: 2.50E+3nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
University of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093592(17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,2,6,7,...)
Affinity DataIC50: 470nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type 2 from human BPH tissue at 210 nM of testosteroneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed