BDBM50093591 17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13-decahydro-cyclopenta[a]phenanthren-3-one::CHEMBL135288

SMILES CC(N=O)C1=CC=C2C3CCC4=CC(=O)CCC4(C)C3CCC12C

InChI Key InChIKey=OOUUPAKSSCFGAA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50093591   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093591(17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8...)
Affinity DataIC50: 200nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rat)
University of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093591(17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8...)
Affinity DataIC50: 1.25E+5nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 rat enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
University of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093591(17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8...)
Affinity DataIC50: 1.00E+4nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type I in human DU-145 cell assay at 5 nM of androstenedioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed