BDBM50092897 3-[3-Chloro-4-(2,4-dichloro-phenylsulfanyl)-phenyl]-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-acrylamide::CHEMBL316691

SMILES Clc1ccc(Sc2ccc(\C=C\C(=O)NCCCN3CCCC3=O)cc2Cl)c(Cl)c1

InChI Key InChIKey=KHWFLVYYKGXMPW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50092897   

TargetIntercellular adhesion molecule 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50092897(3-[3-Chloro-4-(2,4-dichloro-phenylsulfanyl)-phenyl...)
Affinity DataIC50: 700nMAssay Description:Evaluated for its ability to block the adherence of JY-8 cells to immobilized ICAM-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50092897(3-[3-Chloro-4-(2,4-dichloro-phenylsulfanyl)-phenyl...)
Affinity DataIC50: 550nMAssay Description:Ability to block the interaction between integrin LFA-1 and its adhesion partner ICAM-1 in a time-resolved fluorescent LFA-1/ICAM-1 biochemical inter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50092897(3-[3-Chloro-4-(2,4-dichloro-phenylsulfanyl)-phenyl...)
Affinity DataIC50: 550nMAssay Description:Ability to antagonise the Leukocyte function-associated Antigen-1/ Intracellular Adhesion molecule-1 interaction (LFA-1/ICAM-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed