BDBM50092783 CHEMBL3586404

SMILES CO[C@H]1CC[C@@H](CC1)N1C(=O)CNc2ncc(nc12)-c1ccc(nc1)C(C)(C)O

InChI Key InChIKey=UFKLYTOEMRFKAD-UHFFFAOYSA-N

Data  7 IC50  7 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50092783   

LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataIC50: 28nMAssay Description:Inhibition of cFMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataIC50: 651nMAssay Description:Inhibition of Flt4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataIC50: 10nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of PI3K-alpha (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetFKBP12A/mTOR(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataIC50: 30nMAssay Description:Inhibition of mTORC1 in human PC3 cells assessed as inhibition of S6 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataKd:  28nMAssay Description:Inhibition of human mTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataKd:  2.30E+3nMAssay Description:Inhibition of human PI3Kalpha (108 to 1068 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataKd:  7.10E+3nMAssay Description:Inhibition of human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataKd:  39nMAssay Description:Inhibition of human PI4Kbeta (1 to 828 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataKd:  2.50E+3nMAssay Description:Inhibition of human VPS34 (282 to 879 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataKd:  1.80E+4nMAssay Description:Inhibition of human PI3Kbeta (118 to 1070 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataKd:  6.20E+3nMAssay Description:Inhibition of human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataIC50: 16nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed