BDBM50092619 CHEMBL3586359

SMILES Clc1cc(cc2CN(Cc3cc[nH]c(=O)c3)CCOc12)-c1csc2ccccc12

InChI Key InChIKey=HMLTYNGKIGEFDZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50092619   

TargetProstaglandin E2 receptor EP2 subtype(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50092619(CHEMBL3586359)
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50092619(CHEMBL3586359)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of [3H]-PGE2 from human EP1 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50092619(CHEMBL3586359)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of [3H]-PGE2 from human EP3 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50092619(CHEMBL3586359)
Affinity DataIC50: 1.80E+4nMAssay Description:Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50092619(CHEMBL3586359)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed