BDBM50091730 (S)-3-(2-{(R)-1-[2-(2-Amino-pyridin-4-yl)-ethyl]-2-oxo-piperidin-3-yl}-acetylamino)-pent-4-ynoic acid::CHEMBL57191

SMILES Nc1cc(CCN2CCC[C@H](CC(=O)N[C@@H](CC(O)=O)C#C)C2=O)ccn1

InChI Key InChIKey=CRIVUOYMMLIKDM-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50091730   

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091730((S)-3-(2-{(R)-1-[2-(2-Amino-pyridin-4-yl)-ethyl]-2...)
Affinity DataKd:  60nMAssay Description:Binding affinity to resting form of alpha IIb/beta3 integrin by flow cytometry using fluorescein ligand L-726,745 displacement from human platelets.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091730((S)-3-(2-{(R)-1-[2-(2-Amino-pyridin-4-yl)-ethyl]-2...)
Affinity DataIC50: 19nMAssay Description:Inhibition of aggregation of human gel-filtered platelets measured by light transmittance method at 37 degrees C.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091730((S)-3-(2-{(R)-1-[2-(2-Amino-pyridin-4-yl)-ethyl]-2...)
Affinity DataKd:  0.260nMAssay Description:Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed