BDBM50091327 CHEMBL3582251

SMILES CC(C)(C)OC(=O)N1CCN(C(=O)c2cn3nc(cc(c3n2)C(C)(C)C)-c2ccc(F)cc2)C(C)(C)C1

InChI Key InChIKey=UPMAKYFEOQOERX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50091327   

TargetProteinase-activated receptor 2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50091327(CHEMBL3582251)
Affinity DataIC50: 5.00E+4nMAssay Description:Antagonist activity against PAR2 in human HT29 cells assessed as inhibition of UTP-induced Ca2+ responses pre-incubated for 30 mins before UTP stimul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetProteinase-activated receptor 2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50091327(CHEMBL3582251)
Affinity DataIC50: 5.00E+4nMAssay Description:Antagonist activity against PAR2 in human HT29 cells assessed as inhibition of thrombin-induced Ca2+ responses pre-incubated for 30 mins before throm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetProteinase-activated receptor 2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50091327(CHEMBL3582251)
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity against PAR2 in human HT29 cells assessed as inhibition of trypsin-induced Ca2+ responses pre-incubated for 30 mins before trypsi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetProteinase-activated receptor 2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50091327(CHEMBL3582251)
Affinity DataIC50: 4.20nMAssay Description:Antagonist activity against PAR2 in human HT29 cells assessed as inhibition of SLIGKV-induced Ca2+ responses pre-incubated for 30 mins before SLIGKV ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed