BDBM50091087 CHEMBL3582156

SMILES COc1cc(OC)c2C[C@@H](OC(=O)c3ccc(F)c(NC(=O)c4cc(OC)c(OC)c(OC)c4)c3)[C@H](Oc2c1)c1cc(OC)c(OC)c(OC)c1

InChI Key InChIKey=VNMQONKZFZQPCT-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50091087   

TargetATP-dependent translocase ABCB1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50091087(CHEMBL3582156)
Affinity DataEC50:  214nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50091087(CHEMBL3582156)
Affinity DataIC50: 3.30nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversible of paclitaxel resistance measured as IC50 for pa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50091087(CHEMBL3582156)
Affinity DataIC50: 207nMAssay Description:Modulation of BCRP (unknown origin) transfected in human HEK293/R2 cells assessed as potentiation of topotecan-induced cytotoxicity measured as topot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50091087(CHEMBL3582156)
Affinity DataIC50: 418nMAssay Description:Modulation of MRP1 (unknown origin) transfected in human 2008/MRP1 cells assessed as potentiation of doxorubicin-induced cytotoxicity measured as dox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed