BDBM50090831 (-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-dioxa-1-aza-phenanthren-6-ol::CHEMBL97424

SMILES CCCN1CCO[C@@H]2[C@@H]1COc1ccc(O)cc21

InChI Key InChIKey=YOILXOMTHPUMRG-UHFFFAOYSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50090831   

TargetD(2) dopamine receptor(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50090831((-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-diox...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration inhibiting specific binding of [3H]haloperidol to Dopamine receptor D2 from rat striatal brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50090831((-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-diox...)
Affinity DataKi:  5.62E+3nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human D3 receptor expressed in HEK293 cells after 90 mins by microbeta counting based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50090831((-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-diox...)
Affinity DataKi:  7.58E+3nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human D2L receptor expressed in HEK293 cells after 90 mins by microbeta counting based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50090831((-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-diox...)
Affinity DataKi: >1.00E+4nMAssay Description:Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D3 expressed in CHO K-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50090831((-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-diox...)
Affinity DataKi: >1.00E+4nMAssay Description:Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D2L expressed in CHO K-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50090831((-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-diox...)
Affinity DataKi:  7.79E+4nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in HEK293 cells after 60 mins by microbeta counting based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50090831((-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-diox...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed