BDBM50090087 CHEMBL3581534::US9216988, 35

SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2cccc(F)c2)c(F)c1

InChI Key InChIKey=DVZXNFIUEINUHI-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50090087   

TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50090087(CHEMBL3581534 | US9216988, 35)
Affinity DataEC50:  41nMAssay Description:Agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as activa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50090087(CHEMBL3581534 | US9216988, 35)
Affinity DataIC50: 65nMpH: 7.4Assay Description:On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50090087(CHEMBL3581534 | US9216988, 35)
Affinity DataIC50: 65nMAssay Description:Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial express...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed