BDBM50090073 1-(4-Fluoro-phenyl)-1,6-dihydro-[1,3,5]triazine-2,4-diamine::CHEMBL93001

SMILES NC1=NCN(C(N)=N1)c1ccc(F)cc1

InChI Key InChIKey=UZPCXRZSRCSFOL-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50090073   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
Università

Curated by ChEMBL
LigandPNGBDBM50090073(1-(4-Fluoro-phenyl)-1,6-dihydro-[1,3,5]triazine-2,...)
Affinity DataKi:  88nMAssay Description:Inhibition constant against Plasmodium falciparum dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(malaria parasite P. falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandPNGBDBM50090073(1-(4-Fluoro-phenyl)-1,6-dihydro-[1,3,5]triazine-2,...)
Affinity DataKi:  270nMAssay Description:Evaluated for inhibition constant (Ki wt) against Wild-type dihydrofolate reductase of Plasmodium falciparumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [A16V,S108T](malaria parasite P. falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandPNGBDBM50090073(1-(4-Fluoro-phenyl)-1,6-dihydro-[1,3,5]triazine-2,...)
Affinity DataKi:  469nMAssay Description:Inhibition constant (Ki mut) against A16V+S108T Mutant DHFRs of Plasmodium falciparumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed