BDBM50090051 6,6-Dimethyl-1-p-tolyl-1,6-dihydro-[1,3,5]triazine-2,4-diamine::CHEMBL7004

SMILES Cc1ccc(cc1)N1C(N)=NC(N)=NC1(C)C

InChI Key InChIKey=IVICPTLSOMKNRU-UHFFFAOYSA-N

Data  8 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50090051   

TargetDihydrofolate reductase(Escherichia coli)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50090051(6,6-Dimethyl-1-p-tolyl-1,6-dihydro-[1,3,5]triazine...)
Affinity DataKd:  9.32E+3nMAssay Description:Binding affinity to Escherichia coli DHFR at 500 uM using spyro orange reporter dye by differential scanning fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50090051(6,6-Dimethyl-1-p-tolyl-1,6-dihydro-[1,3,5]triazine...)
Affinity DataIC50: 3.23E+4nMAssay Description:Inhibition of Escherichia coli DHFR assessed as NADP formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
Università

Curated by ChEMBL
LigandPNGBDBM50090051(6,6-Dimethyl-1-p-tolyl-1,6-dihydro-[1,3,5]triazine...)
Affinity DataKi:  1.60nMAssay Description:Inhibition constant against Plasmodium falciparum dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(malaria parasite P. falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandPNGBDBM50090051(6,6-Dimethyl-1-p-tolyl-1,6-dihydro-[1,3,5]triazine...)
Affinity DataKi:  1.80nMAssay Description:Evaluated for inhibition constant (Ki wt) against Wild-type dihydrofolate reductase of Plasmodium falciparumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
TBA

Curated by ChEMBL
LigandPNGBDBM50090051(6,6-Dimethyl-1-p-tolyl-1,6-dihydro-[1,3,5]triazine...)
Affinity DataKi:  81nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50090051(6,6-Dimethyl-1-p-tolyl-1,6-dihydro-[1,3,5]triazine...)
Affinity DataKi:  166nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50090051(6,6-Dimethyl-1-p-tolyl-1,6-dihydro-[1,3,5]triazine...)
Affinity DataKi:  1.07E+3nMAssay Description:Inhibitory activity against human lymphoblastoid cell (WIL2) dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50090051(6,6-Dimethyl-1-p-tolyl-1,6-dihydro-[1,3,5]triazine...)
Affinity DataKi:  1.55E+3nMAssay Description:Inhibition of Escherichia coli DHFR assessed as NADP formation by quadratic Morrison plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [A16V,S108T](malaria parasite P. falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandPNGBDBM50090051(6,6-Dimethyl-1-p-tolyl-1,6-dihydro-[1,3,5]triazine...)
Affinity DataKi:  1.58E+3nMAssay Description:Inhibition constant (Ki mut) against A16V+S108T Mutant DHFRs of Plasmodium falciparumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50090051(6,6-Dimethyl-1-p-tolyl-1,6-dihydro-[1,3,5]triazine...)
Affinity DataKi:  6.76E+4nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed