BDBM50089901 2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid::2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid(S-HIBO)::CHEMBL88184

SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O

InChI Key InChIKey=PEHXWVXZPICGAV-UHFFFAOYSA-N

Data  8 KI  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50089901   

TargetGlutamate receptor ionotropic, kainate 1(Rat)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration which causes 50% reduction in receptor binding affinity against Ionotropic glutamate receptor ionotropic kainate using [3H]-kainic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataEC50:  4.90E+5nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataEC50:  2.50E+5nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataKi:  4.90E+5nMAssay Description:The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 5 using established second messenger assay systems.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataKi: >1.00E+6nMAssay Description:The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 2 using established second messenger assay systems.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataKi:  2.50E+5nMAssay Description:The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 1 using established second messenger assay systems.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataKi: >1.00E+6nMAssay Description:The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 4 using established second messenger assay systems.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataKi: >1.00E+6nMAssay Description:Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataKi:  2.50E+5nMAssay Description:Agonist potency against cloned human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataKi:  4.90E+5nMAssay Description:Agonist potency against cloned metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataKi: >1.00E+6nMAssay Description:Antagonist potency against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed