BDBM50089862 CHEMBL3577700

SMILES COc1ccc2C(=O)CC(CC(=O)N[C@@H](CNC(=O)c3ccccc3N3CCC(=O)NC3=O)C(N)=O)c2c1

InChI Key InChIKey=YFRJWFALOKTWJY-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50089862   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Philochem

Curated by ChEMBL
LigandPNGBDBM50089862(CHEMBL3577700)
Affinity DataIC50: 372nMAssay Description:Inhibition of hexa-histidine tagged recombinant tankyrase 1 biotinylated catalytic domain (amino acids 1106 to 1325) (unknown origin) expressed in Es...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Philochem

Curated by ChEMBL
LigandPNGBDBM50089862(CHEMBL3577700)
Affinity DataIC50: 468nMAssay Description:Inhibition of tankyrase 2 catalytic domain (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ADP-ribosyl transferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Philochem

Curated by ChEMBL
LigandPNGBDBM50089862(CHEMBL3577700)
Affinity DataIC50: 28nMAssay Description:Inhibition of full length PARP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ADP-ribosyl transferase activity u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Philochem

Curated by ChEMBL
LigandPNGBDBM50089862(CHEMBL3577700)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of full length PARP10 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ADP-ribosyl transferase activity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Philochem

Curated by ChEMBL
LigandPNGBDBM50089862(CHEMBL3577700)
Affinity DataIC50: 28nMAssay Description:Inhibition of full length PARP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ADP-ribosyl transferase activity u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Philochem

Curated by ChEMBL
LigandPNGBDBM50089862(CHEMBL3577700)
Affinity DataIC50: 470nMAssay Description:Inhibition of tankyrase 2 catalytic domain (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ADP-ribosyl transferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Philochem

Curated by ChEMBL
LigandPNGBDBM50089862(CHEMBL3577700)
Affinity DataIC50: 370nMAssay Description:Inhibition of hexa-histidine tagged recombinant tankyrase 1 biotinylated catalytic domain (amino acids 1106 to 1325) (unknown origin) expressed in Es...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed