BDBM50089770 1-(1,3-Dihydro-isoindol-2-yl)-2-(1H-indol-3-yl)-ethane-1,2-dione::CHEMBL31796

SMILES O=C(N1Cc2ccccc2C1)C(=O)c1c[nH]c2ccccc12

InChI Key InChIKey=XDUPLYSGJVWGTM-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50089770   

TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089770(1-(1,3-Dihydro-isoindol-2-yl)-2-(1H-indol-3-yl)-et...)
Affinity DataKi:  19nMAssay Description:Binding affinity evaluated by ability to displace [3H]Ro-151788 from recombinant human Gamma-aminobutyric acid A receptor alpha-3-beta-3-gamma-2 expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089770(1-(1,3-Dihydro-isoindol-2-yl)-2-(1H-indol-3-yl)-et...)
Affinity DataKi:  200nMAssay Description:Binding affinity evaluated by ability to displace [3H]Ro-151788 from recombinant human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50089770(1-(1,3-Dihydro-isoindol-2-yl)-2-(1H-indol-3-yl)-et...)
Affinity DataKi:  224nMAssay Description:Inhibition of [3H]flumazenil binding to rat alpha-1-beta-2-gamma-2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089770(1-(1,3-Dihydro-isoindol-2-yl)-2-(1H-indol-3-yl)-et...)
Affinity DataKi:  1.30E+3nMAssay Description:Binding affinity evaluated by ability to displace [3H]-Ro-15-1788 from recombinant human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50089770(1-(1,3-Dihydro-isoindol-2-yl)-2-(1H-indol-3-yl)-et...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of [3H]flumazenil binding to rat alpha-3-beta-2-gamma-2 GABA-A receptor subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed