BDBM50089657 CHEMBL3577298

SMILES CC1=C(C)C(=O)C(CONC(=O)CCCCCCC(=O)Nc2ccccc2)=C(C)C1=O

InChI Key InChIKey=HXFDEOSGMWWMSA-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50089657   

TargetHistone deacetylase 3(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50: 149nMAssay Description:Inhibition of human recombinant HDAC3 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50: 255nMAssay Description:Inhibition of human recombinant HDAC2 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50: 371nMAssay Description:Inhibition of human recombinant HDAC1 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant HDAC6 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of human recombinant HDAC8 using MAZ1675 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataKi:  250nMAssay Description:Binding affinity to human Zn2+-HDAC8 assessed as loss of activity by Fluor-de-Lys activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataKi:  7.00E+3nMAssay Description:Reversible-time dependent inhibition of human wild type HDAC8 by Fluor-de-Lys activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed