BDBM50089633 CHEMBL3578274

SMILES C[C@@H](N1C(=O)O[C@@](Cc2ccccc2)(C1=O)c1nc2cc(ccc2[nH]1)C(F)(F)F)c1ccc(F)cc1

InChI Key InChIKey=SAHIAXKCYNHCNR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50089633   

TargetMineralocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089633(CHEMBL3578274)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at human mineralocorticoid receptor overexpressed in CHOK1 cells assessed as inhibition of aldosterone-induced protein interactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089633(CHEMBL3578274)
Affinity DataIC50: 3.40E+3nMAssay Description:Antagonist activity at human glucocorticoid receptor expressed in CHOK1 cells assessed as inhibition of dexamethasone-induced protein interaction wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089633(CHEMBL3578274)
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at human androgen receptor expressed in CHOK1 cells assessed as inhibition of D(-)-norgestrel-induced protein interaction with st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089633(CHEMBL3578274)
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at human estrogen receptor alpha expressed in CHOK1 cells assessed as inhibition of beta-estradiol-induced protein interaction wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089633(CHEMBL3578274)
Affinity DataIC50: 2.70E+3nMAssay Description:Antagonist activity at human estrogen receptor beta assessed as inhibition of agonist-induced protein interaction with steroid receptor co-activator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089633(CHEMBL3578274)
Affinity DataIC50: 3.20E+3nMAssay Description:Antagonist activity at human progesterone receptor beta expressed in human U2OS cells assessed as inhibition of D(-)-norgestrel-induced protein inter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed