BDBM50089584 CHEMBL3578252::US9914740, VIII-15

SMILES CCC1Oc2cnccc2-c2ccc(cc12)C(=O)N[C@H](C)c1cccc(OC)c1

InChI Key InChIKey=TUQZDIZIVRTIGP-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50089584   

TargetRho-associated protein kinase 2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of ROCK2 (unknown origin) using substrate FITC-AHA- AKRRRLSSLRA-OHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50: 0.560nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed