BDBM50088899 2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzylamino)ethanol::2-{4-[4-Amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-benzylamino}-ethanol::CHEMBL424375

SMILES COc1cccc(c1)-c1cn(-c2ccc(CNCCO)cc2)c2ncnc(N)c12

InChI Key InChIKey=QGPSFIYTQAONCS-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50088899   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088899(2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50: 600nMAssay Description:Inhibition of PDGF-receptor kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1/ABL2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088899(2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50: 230nMAssay Description:Tested in vitro for inhibition of non-receptor tyrosine kinase v-AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088899(2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Tested in vitro for inhibition of serine/threonine kinase Cdc2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088899(2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50: 5.00E+3nMAssay Description:Tested for inhibition of protein tyrosine kinase Csk phosphorylation in intact cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088899(2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50: 500nMAssay Description:Tested for inhibition of protein tyrosine kinase c-Src phosphorylation in intact cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088899(2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50: 300nMAssay Description:Tested for inhibition of EGF-receptor tyrosine kinase in intact cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088899(2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50: 30nMAssay Description:Tested for inhibition of protein tyrosine kinase c-Src phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088899(2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50: 1.00E+3nMAssay Description:Tested in vitro for inhibition of KDR-receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088899(2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50: 6.40E+3nMAssay Description:Tested for inhibition of EGF-receptor tyrosine kinase in intact cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088899(2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50: 31.6nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088899(2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50: 32nMAssay Description:Inhibition of c-Src kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article