BDBM50088872 2-(8-fluoro-4-methyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-1-ethanamine::CHEMBL355474

SMILES CC1CCc2cc(F)cc3c(CCN)cn1c23

InChI Key InChIKey=IMICWWRDHASRGJ-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50088872   

Target5-hydroxytryptamine receptor 2A(Human)
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50088872(2-(8-fluoro-4-methyl-5,6-dihydro-4H-pyrrolo[3,2,1-...)
Affinity DataEC50:  269nMAssay Description:Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2a receptor c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50088872(2-(8-fluoro-4-methyl-5,6-dihydro-4H-pyrrolo[3,2,1-...)
Affinity DataEC50:  5.70nMAssay Description:Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50088872(2-(8-fluoro-4-methyl-5,6-dihydro-4H-pyrrolo[3,2,1-...)
Affinity DataKi:  18nMAssay Description:In vitro binding affinity towards human 5-hydroxytryptamine 2C receptor expressed in HEK293 cells was determined using [3H]mesulergine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50088872(2-(8-fluoro-4-methyl-5,6-dihydro-4H-pyrrolo[3,2,1-...)
Affinity DataKi:  2.34E+3nMAssay Description:In vitro binding affinity towards human 5-hydroxytryptamine 2A receptor expressed in HEK293 cells was determined using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed