BDBM50087135 CHEMBL3426621

SMILES C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(F)c12

InChI Key InChIKey=QSKQVZWVLOIIEV-UHFFFAOYSA-N

Data  1 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50087135   

TargetRho-associated protein kinase 2(Human)
Agoralaan Abis

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Agoralaan Abis

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 197nMAssay Description:Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 51nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Agoralaan Abis

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 19nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Agoralaan Abis

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 19nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 51nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Agoralaan Abis

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 19nMAssay Description:Inhibition of N-terminal GST-fused human ROCK2 catalytic domain ( 1 to 553 residues) expressed in baculovirus expression system using Long S6 Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 51nMAssay Description:Inhibition of N-terminal GST-fused human ROCK1 catalytic domain ( 1 to 477 residues) expressed in baculovirus expression system using Long S6 Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 64nMAssay Description:Inhibition of ROCK1 (unknown origin) using biotin as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Agoralaan Abis

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 21nMAssay Description:Inhibition of ROCK2 (unknown origin) using biotin as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 51nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Agoralaan Abis

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 19nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 51nMAssay Description:Inhibition of Rock1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Agoralaan Abis

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 19nMAssay Description:Inhibition of Rock2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Agoralaan Abis

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataKi:  330nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed