BDBM50086623 CHEMBL336039::Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-6-(pyridin-3-ylcarbamoyl)-1,2-dihydro-quinolin-4-yloxy]-ethyl}-piperidinium;

SMILES Cc1cc(C)cc(c1)-c1c(OCCC2CCCC[NH2+]2)c2cc(C(=O)Nc3cccnc3)c(Cl)cc2[nH]c1=O

InChI Key InChIKey=XVGQYNJHKKYLAU-UHFFFAOYSA-O

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50086623   

TargetGonadotropin-releasing hormone receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086623(Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-ph...)
Affinity DataIC50: 1.28E+3nMAssay Description:In vitro inhibition of GnRH stimulated release of luteinizing hormone from the rat primary pituitary cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086623(Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-ph...)
Affinity DataIC50: 130nMAssay Description:In vitro inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells stably expressing gonadotropin-releasing hormone receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086623(Trifluoro-acetate2-{2-[7-chloro-3-(3,5-dimethyl-ph...)
Affinity DataIC50: 32nMAssay Description:In vitro inhibitory activity against rat CHO cells stably expressing human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed