BDBM50086553 6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihydro-quinoline::6-(4-bromothiophen-2-yl)-2,2,4-trimethyl-1,2-dihydroquinoline::CHEMBL538158

SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cc(Br)cs1

InChI Key InChIKey=QRGCGNOXVSPDPZ-UHFFFAOYSA-N

Data  2 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50086553   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086553(6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihy...)
Affinity DataIC50: 105nMAssay Description:Antagonist activity against human progesterone receptor (hPR) using cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086553(6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihy...)
Affinity DataIC50: 190nMAssay Description:Antagonist activity against human progesterone receptor (hPR) in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086553(6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihy...)
Affinity DataEC50:  2.70E+3nMAssay Description:Human progesterone receptor (hPR) agonist activity expressed in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086553(6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihy...)
Affinity DataEC50:  3.50E+3nMAssay Description:Human progesterone receptor (hPR) agonist activity in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086553(6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihy...)
Affinity DataKi:  32nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086553(6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihy...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed