BDBM50086550 4-Methyl-5-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-thiophene-2-carbonitrile::4-methyl-5-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carbonitrile::CHEMBL132889

SMILES Cc1cc(sc1-c1ccc2NC(C)(C)C(=O)C(C)(C)c2c1)C#N

InChI Key InChIKey=MWIXIWILHMYRGD-UHFFFAOYSA-N

Data  3 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50086550   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086550(4-methyl-5-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetr...)
Affinity DataEC50:  350nMAssay Description:Human progesterone receptor (hPR) agonist activity expressed in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086550(4-methyl-5-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetr...)
Affinity DataIC50: 150nMAssay Description:Cross-reactivity as binding to human androgen receptor (hAR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086550(4-methyl-5-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetr...)
Affinity DataIC50: 2.10E+3nMAssay Description:Cross-reactivity as binding to human mineralocorticoid receptor (hMR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086550(4-methyl-5-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetr...)
Affinity DataIC50: 35nMAssay Description:Cross-reactivity as binding to human glucocorticoid receptor (hGR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086550(4-methyl-5-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetr...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity against human progesterone receptor (hPR) using cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086550(4-methyl-5-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetr...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to human progesterone receptor by competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086550(4-methyl-5-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetr...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086550(4-methyl-5-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetr...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed