BDBM50086536 2,2,4-Trimethyl-6-(3-methyl-thiophen-2-yl)-1,2-dihydro-quinoline::2,2,4-trimethyl-6-(3-methylthiophen-2-yl)-1,2-dihydroquinoline::CHEMBL133794

SMILES Cc1ccsc1-c1ccc2NC(C)(C)C=C(C)c2c1

InChI Key InChIKey=KDEPJXRAESNIQG-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50086536   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086536(2,2,4-Trimethyl-6-(3-methyl-thiophen-2-yl)-1,2-dih...)
Affinity DataIC50: 232nMAssay Description:Antagonist activity against human progesterone receptor (hPR) using cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086536(2,2,4-Trimethyl-6-(3-methyl-thiophen-2-yl)-1,2-dih...)
Affinity DataIC50: 105nMAssay Description:Antagonist activity against human progesterone receptor (hPR) in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086536(2,2,4-Trimethyl-6-(3-methyl-thiophen-2-yl)-1,2-dih...)
Affinity DataKi:  25nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086536(2,2,4-Trimethyl-6-(3-methyl-thiophen-2-yl)-1,2-dih...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed