BDBM50085910 (Z)-7-{(1R,2R,3R,5S)-2-[(E)-(R)-4-(3-Chloro-phenoxy)-3-hydroxy-but-1-enyl]-3,5-dihydroxy-cyclopentyl}-hept-5-enoic acid::7-{2-[4-(3-Chloro-phenoxy)-3-hydroxy-but-1-enyl]-3,5-dihydroxy-cyclopentyl}-hept-5-enoic acid::CHEMBL37853::CLOPROSTENOL

SMILES c1cc(cc(c1)Cl)OC[C@@H](/C=C/[C@H]2[C@@H](C[C@@H]([C@@H]2C/C=C\CCCC(=O)O)O)O)O

InChI Key InChIKey=VJGGHXVGBSZVMZ-UHFFFAOYSA-N

Data  12 KI  9 IC50  4 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50085910   

TargetProstaglandin E2 receptor EP3 subtype(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataEC50:  5.00E+3nMAssay Description:Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3(% of control ligand, sulprostone=75%)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataEC50:  10nMAssay Description:Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThromboxane A2 receptor(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Affinity for Prostanoid TP receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstacyclin receptor(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Affinity for Prostaglandin I2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 635nMAssay Description:Affinity for Prostanoid EP3 receptor expressed in CHO cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Affinity for human Prostaglandin D2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Affinity for Prostanoid EP4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 496nMAssay Description:Affinity for Prostanoid EP1 receptor expressed in COS-7 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 3.70E+3nMAssay Description:Affinity for Prostanoid EP2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 2nMAssay Description:Affinity for human Prostanoid FP receptor expressed in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E2 receptor EP1 subtype(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataEC50:  760nMAssay Description:Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP1 (% of control ligand, 17-phi-PGE2=80%)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataEC50:  2.40E+3nMAssay Description:Functional activity in RAT-1cells, transiently-transfected with human TP-receptor (% of control ligand, [3H]-U-46,619=100%)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin F2-alpha receptor(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin F2-alpha receptor(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  0.470nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E2 receptor EP3 subtype(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  4.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetProstaglandin F2-alpha receptor(Bovine)
Alcon Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  31nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  31nMAssay Description:Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E2 receptor EP3 subtype(Bovine)
Alcon Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Bovine)
Alcon Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  91nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  815nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetSolute carrier organic anion transporter family member 2A1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  6.12E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi:  9.14E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50085910(CLOPROSTENOL | CHEMBL37853 | (Z)-7-{(1R,2R,3R,5S)-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed