BDBM50085526 (E)-3,5,30,40-Tetramethoxystilbene::4-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-1,2-dimethoxybenzene::4-[2-(3,5-dimethoxyphenyl)-(E)-1-ethenyl]-1,2-dimethoxybenzene::CHEMBL44509

SMILES COc1cc(OC)cc(\C=C\c2ccc(OC)c(OC)c2)c1

InChI Key InChIKey=PTVAOGIYBMTHSN-UHFFFAOYSA-N

Data  1 KI  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50085526   

TargetCytochrome P450 1A1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085526(4-[2-(3,5-dimethoxyphenyl)-(E)-1-ethenyl]-1,2-dime...)
Affinity DataIC50: 750nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes epressing human cytochrome P450 1A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085526(4-[2-(3,5-dimethoxyphenyl)-(E)-1-ethenyl]-1,2-dime...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes expressing human cytochrome P450 1B1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085526(4-[2-(3,5-dimethoxyphenyl)-(E)-1-ethenyl]-1,2-dime...)
Affinity DataIC50: 5.70E+5nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes expressing human cytochrome P450 1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50085526(4-[2-(3,5-dimethoxyphenyl)-(E)-1-ethenyl]-1,2-dime...)
Affinity DataIC50: 3.71E+4nMAssay Description:Inhibition of human quinone reductase 2 expressed in Escherichia coli BL21(DE3) using N-methyldihydronicotinamide as co-substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Dr. Harisingh Gour University

Curated by ChEMBL
LigandPNGBDBM50085526(4-[2-(3,5-dimethoxyphenyl)-(E)-1-ethenyl]-1,2-dime...)
Affinity DataIC50: 160nMAssay Description:Inhibition of wildtype ABCG2 (unknown origin) transfected in HEK293 cells measured after 30 mins by flow cytometric anlaysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Dr. Harisingh Gour University

Curated by ChEMBL
LigandPNGBDBM50085526(4-[2-(3,5-dimethoxyphenyl)-(E)-1-ethenyl]-1,2-dime...)
Affinity DataIC50: 160nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in human HEK293 cells assessed as reversal of BCRP-mediated mitoxantrone resistance and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50085526(4-[2-(3,5-dimethoxyphenyl)-(E)-1-ethenyl]-1,2-dime...)
Affinity DataKd:  6.90E+3nMAssay Description:Binding affinity to recombinant N-terminal hexa-histidine tagged TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as quenching...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50085526(4-[2-(3,5-dimethoxyphenyl)-(E)-1-ethenyl]-1,2-dime...)
Affinity DataKi:  4.90E+4nMAssay Description:Inhibition of recombinant N-terminal hexa-histidine tagged TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as acid mediated a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed