BDBM50085339 ((S)-1-Benzyl-3-chloro-2-oxo-propyl)-carbamic acid benzyl ester::CHEMBL303579::acs.jmedchem.1c00409_ST.138

SMILES c1ccc(cc1)C[C@@H](C(=O)CCl)NC(=O)OCc2ccccc2

InChI Key InChIKey=OYHLRJGDELITAF-UHFFFAOYSA-N

Data  1 KI  7 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50085339   

TargetChymotrypsinogen A(Bovine)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50085339(((S)-1-Benzyl-3-chloro-2-oxo-propyl)-carbamic acid...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibitory activity against alpha-chymotrypsin (alpha-CT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin G(Human)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50085339(((S)-1-Benzyl-3-chloro-2-oxo-propyl)-carbamic acid...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibitory activity against human leukocyte cathepsin GMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50085339(((S)-1-Benzyl-3-chloro-2-oxo-propyl)-carbamic acid...)
Affinity DataIC50: 400nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymotrypsin-like elastase family member 2A(Pig)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50085339(((S)-1-Benzyl-3-chloro-2-oxo-propyl)-carbamic acid...)
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibitory activity against porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypsin(Pig)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50085339(((S)-1-Benzyl-3-chloro-2-oxo-propyl)-carbamic acid...)
Affinity DataIC50: 2.10E+5nMAssay Description:Inhibitory activity against porcine pancreatic trypsin (TRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50085339(((S)-1-Benzyl-3-chloro-2-oxo-propyl)-carbamic acid...)
Affinity DataIC50: 630nMAssay Description:Inhibition of Atg4B (unknown origin) using YFP-LC3B-EmGFP as substrate after 40 mins by FRET-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2018
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50085339(((S)-1-Benzyl-3-chloro-2-oxo-propyl)-carbamic acid...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of ATG4B (unknown origin) using proLC3B as substrate by FRET-LC3 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Michigan State University

LigandPNGBDBM50085339(((S)-1-Benzyl-3-chloro-2-oxo-propyl)-carbamic acid...)
Affinity DataKi:  310nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed