BDBM50085245 1-[2-(4-Phenoxy-phenoxy)-ethyl]-pyrrolidine::CHEMBL162424

SMILES C(CN1CCCC1)Oc1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=VIJWTJWNQTYPSK-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50085245   

TargetProstaglandin G/H synthase 1(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50085245(1-[2-(4-Phenoxy-phenoxy)-ethyl]-pyrrolidine | CHEM...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of purified COX1 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50085245(1-[2-(4-Phenoxy-phenoxy)-ethyl]-pyrrolidine | CHEM...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50085245(1-[2-(4-Phenoxy-phenoxy)-ethyl]-pyrrolidine | CHEM...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50085245(1-[2-(4-Phenoxy-phenoxy)-ethyl]-pyrrolidine | CHEM...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of purified COX2 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50085245(1-[2-(4-Phenoxy-phenoxy)-ethyl]-pyrrolidine | CHEM...)
Affinity DataIC50: 780nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50085245(1-[2-(4-Phenoxy-phenoxy)-ethyl]-pyrrolidine | CHEM...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity was determined against Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50085245(1-[2-(4-Phenoxy-phenoxy)-ethyl]-pyrrolidine | CHEM...)
Affinity DataIC50: 79nMAssay Description:Inhibitory activity was determined for LTB4 production in human whole blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed