BDBM50084855 CHEMBL423361::Cyclohexanecarboxylic acid {2-[4-(2-hydroxy-phenyl)-piperazin-1-yl]-ethyl}-pyridin-2-yl-amide

SMILES Oc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1

InChI Key InChIKey=GSYXUBWRYIWXJK-UHFFFAOYSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50084855   

Target5-hydroxytryptamine receptor 1A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50084855(Cyclohexanecarboxylic acid {2-[4-(2-hydroxy-phenyl...)
Affinity DataIC50: 2.10nMAssay Description:In vitro affinity against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT in rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Vu University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084855(Cyclohexanecarboxylic acid {2-[4-(2-hydroxy-phenyl...)
Affinity DataIC50: 0.770nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in HEK293 EBNA cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Vu University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084855(Cyclohexanecarboxylic acid {2-[4-(2-hydroxy-phenyl...)
Affinity DataIC50: 0.770nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 EBNA cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Vu University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084855(Cyclohexanecarboxylic acid {2-[4-(2-hydroxy-phenyl...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in HEK293 EBNA cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Vu University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084855(Cyclohexanecarboxylic acid {2-[4-(2-hydroxy-phenyl...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 EBNA cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Vu University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084855(Cyclohexanecarboxylic acid {2-[4-(2-hydroxy-phenyl...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50084855(Cyclohexanecarboxylic acid {2-[4-(2-hydroxy-phenyl...)
Affinity DataKi:  364nMAssay Description:Binding affinity to alpha 1A adrenergic receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed