BDBM50084217 (R)-4-Methylene-1-(4-phenoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid hydroxyamide::CHEMBL356011

SMILES ONC(=O)[C@H]1CC(=C)CN1S(=O)(=O)c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=CYBDDZKSRZPTQR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50084217   

Target72 kDa type IV collagenase(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50084217((R)-4-Methylene-1-(4-phenoxy-benzenesulfonyl)-pyrr...)
Affinity DataIC50: 0.400nMAssay Description:In vitro inhibitory activity against gelatinase-A (matrix metalloprotease-2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50084217((R)-4-Methylene-1-(4-phenoxy-benzenesulfonyl)-pyrr...)
Affinity DataIC50: 53nMAssay Description:In vitro inhibition of matrilysin (Matrix metalloprotease-7, MMP-7)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50084217((R)-4-Methylene-1-(4-phenoxy-benzenesulfonyl)-pyrr...)
Affinity DataIC50: 15nMAssay Description:In vitro inhibition of human recombinant collagenase-1 (Matrix metalloprotease-1, MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50084217((R)-4-Methylene-1-(4-phenoxy-benzenesulfonyl)-pyrr...)
Affinity DataIC50: 14nMAssay Description:In vitro inhibition activity of human recombinant stromelysin (Matrix metalloprotease-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed