BDBM50083641 Aminopyrimidine (Scaffold II)::CHEMBL113185::N*1*-{5-[2-(3,4,5-Trimethoxy-phenylamino)-pyrimidin-4-yl]-pyridin-2-yl}-ethane-1,2-diamine

SMILES COc1cc(Nc2nccc(n2)-c2ccc(NCCN)nc2)cc(OC)c1OC

InChI Key InChIKey=QNULKTUETCUJKC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50083641   

TargetSerine/threonine-protein kinase TBK1(Human)
Technical University of Dortmund

LigandPNGBDBM50083641(N*1*-{5-[2-(3,4,5-Trimethoxy-phenylamino)-pyrimidi...)
Affinity DataIC50: 160nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083641(N*1*-{5-[2-(3,4,5-Trimethoxy-phenylamino)-pyrimidi...)
Affinity DataIC50: 125nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083641(N*1*-{5-[2-(3,4,5-Trimethoxy-phenylamino)-pyrimidi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of csk tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083641(N*1*-{5-[2-(3,4,5-Trimethoxy-phenylamino)-pyrimidi...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of Epidermal growth factor receptor (EGFr)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083641(N*1*-{5-[2-(3,4,5-Trimethoxy-phenylamino)-pyrimidi...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50083641(N*1*-{5-[2-(3,4,5-Trimethoxy-phenylamino)-pyrimidi...)
Affinity DataIC50: 150nMAssay Description:Inhibition of protein kinase C (PKC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed