BDBM50083406 CHEMBL430778::[1-(3H-Imidazol-4-ylmethyl)-7-pyridin-4-yl-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-(2-trifluoromethoxy-phenyl)-methanone

SMILES FC(F)(F)Oc1ccccc1C(=O)N1CCN(Cc2cnc[nH]2)c2ccc(cc2C1)-c1ccncc1

InChI Key InChIKey=YBROKHNFEQXGSA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50083406   

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083406([1-(3H-Imidazol-4-ylmethyl)-7-pyridin-4-yl-1,2,3,5...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibitory activity against human purified recombinant farnesyltransferase (hFT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083406([1-(3H-Imidazol-4-ylmethyl)-7-pyridin-4-yl-1,2,3,5...)
Affinity DataIC50: 24nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed