BDBM50083214 2-[(E)-3-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-propenyl]-phenol::CHEMBL145903

SMILES Oc1ccccc1\C=C\CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1

InChI Key InChIKey=LCGMVNDXDILPJF-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50083214   

TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50083214(2-[(E)-3-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-eth...)
Affinity DataIC50: 397nMAssay Description:Reuptake inhibition of [3H]-5-HT (5-HT) in rat.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50083214(2-[(E)-3-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-eth...)
Affinity DataIC50: 7nMAssay Description:Reuptake inhibition of [3H]-labeled dopamine (DA) in rat.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50083214(2-[(E)-3-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-eth...)
Affinity DataKi:  0.920nMAssay Description:Binding affinity against dopamine transporter labelled with [125I]- RTI-55 in rat.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50083214(2-[(E)-3-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-eth...)
Affinity DataKi:  27nMAssay Description:Binding affinity against Serotonin transporter (SERT) labelled with [125I]RTI-55 in rat.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed