BDBM50081954 (R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (4-chloro-phenyl)-amide::CHEMBL135959

SMILES FC[C@H]1Cc2ccc(cc2CN1)S(=O)(=O)Nc1ccc(Cl)cc1

InChI Key InChIKey=ZVBJVGBGWLUEOH-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50081954   

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50081954((R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline...)
Affinity DataKi:  110nMAssay Description:In vitro binding affinity against recombinant human Phenylethanolamine N-methyl-transferase expressed in Escherichia coli using [methyl-3H]-AdoMetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Bovine)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50081954((R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline...)
Affinity DataKi:  280nMAssay Description:In vitro inhibition of PNMT (Phenylethanolamine N-Methyltransferase).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor [16-465](Rat)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50081954((R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline...)
Affinity DataKi:  1.40E+5nMAssay Description:In vitro binding affinity against rat Alpha-2 adrenergic receptor using [3H]clonidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed