BDBM50081919 3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol::CHEMBL30734

SMILES Nc1ncc(Cc2cccc(O)c2)c(N)n1

InChI Key InChIKey=QBQBQHCSEMOJAW-UHFFFAOYSA-N

Data  16 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50081919   

TargetDihydrofolate reductase(Escherichia coli)
Uniroyal Chemical

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  338nMAssay Description:Inhibition constant against binding of Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2019
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Uniroyal Chemical

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  339nMAssay Description:Apparent inhibitory (log 1/Ki) activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Uniroyal Chemical

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  339nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli (expressed as log 1/Kiapp)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Salmonella typhi)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  339nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Uniroyal Chemical

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  339nMAssay Description:Compound is evaluated for the inhibition of dihydrofolate reductase from Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  750nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Leishmania major.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  990nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Trypanosoma cruzi.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  1.51E+3nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  1.51E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Lactobacillus casei (expressed as log 1/Kiapp)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  1.32E+4nMpH: 7.2Assay Description:Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  1.32E+4nMpH: 7.2Assay Description:Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  1.32E+4nMAssay Description:Inhibition of dihydrofolate reductase from bovine liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  1.35E+5nMAssay Description:Inhibitory activity against chicken liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  1.35E+5nMpH: 7.2Assay Description:Inhibitory activity against chicken dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50081919(3-(2,4-Diamino-pyrimidin-5-ylmethyl)-phenol | CHEM...)
Affinity DataKi:  1.35E+5nMpH: 7.2Assay Description:Inhibitory activity against chicken dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2018
Entry Details Article
PubMed