BDBM50081588 1-(2,4-Diamino-5,6,7,8-tetrahydro-pteridin-6-yl)-propane-1,2-diol::CHEMBL318427

SMILES C[C@@H]([C@@H]([C@H]1CNc2c(c(nc(n2)N)N)N1)O)O

InChI Key InChIKey=NDSDGUULXHNXGA-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50081588   

TargetNitric oxide synthase, endothelial(Pig)
Julius-Maximilians University WüRzburg

Curated by ChEMBL
LigandPNGBDBM50081588(1-(2,4-Diamino-5,6,7,8-tetrahydro-pteridin-6-yl)-p...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibitory activity against Nitric oxide synthase (derived from porcine brain cerebellum)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50081588(1-(2,4-Diamino-5,6,7,8-tetrahydro-pteridin-6-yl)-p...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (NOS-I)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50081588(1-(2,4-Diamino-5,6,7,8-tetrahydro-pteridin-6-yl)-p...)
Affinity DataIC50: 5.46E+3nMAssay Description:Inhibitory activity against human Nitric oxide synthase-III with 2 uM H4Bip for 30 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50081588(1-(2,4-Diamino-5,6,7,8-tetrahydro-pteridin-6-yl)-p...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibitory activity against human Nitric oxide synthase-II with 2 uM H4Bip for 30 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50081588(1-(2,4-Diamino-5,6,7,8-tetrahydro-pteridin-6-yl)-p...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibitory activity against human Nitric oxide synthase-I with 2 uM H4Bip for 30 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed