BDBM50081190 CHEMBL3421979

SMILES Cc1nccc(n1)-c1c[nH]c2cnccc12

InChI Key InChIKey=VAXXXDBEUYQWBN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50081190   

TargetInsulin-like growth factor 1 receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50081190(CHEMBL3421979)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged IGF-1R using fluorescence substrate after 80 mins by caliper off-chip incubation mobility shif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
LigandPNGBDBM50081190(CHEMBL3421979)
Affinity DataIC50: 3.07E+3nMAssay Description:Inhibition of human full length C-terminal c-Myc tagged Dyrk1B phosphorylation overexpressed in monkey COS1 cells after 5 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
LigandPNGBDBM50081190(CHEMBL3421979)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant Dyrk1B (unknown origin) using FITC-Asp-His-Thr-Gly-Phe-Leu-Thr-Glu-Tyr-Val-Ala-Thr-Arg-NH2 as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50081190(CHEMBL3421979)
Affinity DataIC50: 3.84E+4nMAssay Description:Inhibition of human recombinant full length C-terminal His6-tagged CDK2 expressed in baculovirus infected Sf21 insect cells using fluorescence substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50081190(CHEMBL3421979)
Affinity DataIC50: 19nMAssay Description:Inhibition of full-length recombinant human GST-tagged Dyrk1a expressed in baculovirus expression system using Alexa-Fluor tracer-236 incubated for 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed