BDBM50080575 CHEMBL3126602::US9617250, Example 2

SMILES CCCc1cc(ccn1)-c1nc(no1)-c1cc(C)c(OC[C@@H](O)CNC(=O)CO)c(CC)c1

InChI Key InChIKey=VYUYMNNZGDEJLE-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50080575   

TargetSphingosine 1-phosphate receptor 1(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50080575(CHEMBL3126602 | US9617250, Example 2)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human recombinant S1P1 receptor expressed in CHO cells incubated for 30 mins prior to 35SGTP-gammaS addition measured after 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50080575(CHEMBL3126602 | US9617250, Example 2)
Affinity DataEC50:  1.12E+3nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells incubated for 30 mins prior to 35SGTP-gammaS addition measured after 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50080575(CHEMBL3126602 | US9617250, Example 2)
Affinity DataEC50:  0.700nMAssay Description:GTPγS binding assays are performed in 96 well microtiter plates (Nunc, 442587) in a final volume of 200 μl, using membrane preparations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50080575(CHEMBL3126602 | US9617250, Example 2)
Affinity DataEC50:  1.12E+3nMAssay Description:GTPγS binding assays are performed in 96 well microtiter plates (Nunc, 442587) in a final volume of 200 μl, using membrane preparations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50080575(CHEMBL3126602 | US9617250, Example 2)
Affinity DataEC50:  1.12E+3nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells incubated for 30 mins prior to [35S]-GTPgammaS addition measured after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50080575(CHEMBL3126602 | US9617250, Example 2)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human recombinant S1P1 receptor expressed in CHO cells incubated for 30 mins prior to [35S]-GTPgammaS addition measured after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed